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Spinal Muscular Atrophy - Type 3 & 4

SMA type 3 is a mild form of SMA and usually manifests after 18 months of age. Most children with type 3 SMA are able to stand and walk. Proximal muscle weakness progresses slowly and muscles of the throat and mouth are affected late in the course of the disease. Usually, life expectancy is normal. [2]

SMA type 4 or adult onset SMA typically presents after the 3rd decade of life with gradual weakening of proximal muscles of the extremities, frequently causing patients to become wheelchair-bound in the end. Complications associated with more serious types of SMA are rare, and patients have normal life expectancy. [3]

3. SMA. Wikipedia, the free encyclopedia. Retrieved from
4. Robert T. Leshner. Retrieved from

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